Permission issues running homebrew scripts

So, I keep getting stuff like this when doing updates, installs, and upgrades. Any ideas?

Molly:Downloads Binary$ brew update
/usr/local/Homebrew/Library/Homebrew/cmd/ line 78: /usr/bin/tr: Permission denied
/usr/local/Homebrew/Library/Homebrew/cmd/ line 78: /usr/bin/tr: Permission denied
fatal: cannot exec 'gc': Permission denied
Already up-to-date.
Molly:Downloads Binary$

Do you have a multi-user setup? /usr/bin first in your path? An agressive virus scanner/device manager?

Multi-user setup? Not exactly? Just basic only user on a Mac 10.14.6.

AV scanner? Not really. I’m running Trend Micro and Micro Snitch. But, it would have notified me if something was up.

/usr/bin? Nope. I’ve been trying to muck with that. But, the system default PATH is doesn’t have it as the first.
Molly:database Binary$ echo $PATH

That’s odd. What does ls -al /usr/bin/tr tell you?

Molly:~ Binary$ ls -al /usr/bin/tr
-rwxr-xr-x 1 root wheel 27744 May 3 21:04 /usr/bin/tr
Molly:~ Binary$ which tr
Molly:~ Binary$ id
uid=501(Binary) gid=20(staff) groups=20(staff),501(access_bpf),701(,12(everyone),61(localaccounts),79(_appserverusr),80(admin),81(_appserveradm),98(_lpadmin),702(,33(_appstore),100(_lpoperator),204(_developer),250(_analyticsusers),395(,398(,399(

Any ideas? Still getting the same error for various commands that the homebrew script uses.